Tetracyclines convert the osteoclastic-differentiation pathway of progenitor cells to produce dendritic cell-like cells.

@article{Kinugawa2012TetracyclinesCT,
  title={Tetracyclines convert the osteoclastic-differentiation pathway of progenitor cells to produce dendritic cell-like cells.},
  author={Saya Kinugawa and Masanori Koide and Yasuhiro Kobayashi and Toshihide Mizoguchi and Tadashi Ninomiya and Akinori Muto and Ichiro Kawahara and Midori Nakamura and Hisataka Yasuda and Naoyuki Takahashi and Nobuyuki Udagawa},
  journal={Journal of immunology},
  year={2012},
  volume={188 4},
  pages={1772-81}
}
Tetracyclines, such as doxycycline and minocycline, are used to suppress the growth of bacteria in patients with inflammatory diseases. Tetracyclines have been shown to prevent bone loss, but the mechanism involved is unknown. Osteoclasts and dendritic cells (DCs) are derived from common progenitors, such as bone marrow-derived macrophages (BMMs). In this article, we show that tetracyclines convert the differentiation pathway, resulting in DC-like cells not osteoclasts. Doxycycline and… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…