Tetracycline resistance mediated by ribosomal protection.

@article{Taylor1996TetracyclineRM,
  title={Tetracycline resistance mediated by ribosomal protection.},
  author={Diane E. Taylor and Andrew S. Chau},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 1},
  pages={1-5}
}
Resistance to tetracycline may be mediated by one of three different mechanisms: (i) an energy-dependent efflux of tetracycline brought about by an integral membrane protein (20); (ii) ribosomal protection by a soluble protein (5, 23), or (iii) enzymatic inactivation of tetracycline (33), which occurs rarely. This minireview concentrates exclusively on the second mechanism of tetracycline resistance. 

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Tet(O), a protein that mediates ribosomal protection to tetracycline, binds, and hydrolyses GTP

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