Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene.

@article{Dugan2004TetracyclineRI,
  title={Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene.},
  author={Jae Dugan and Daniel D. Rockey and Loren Jones and Arthur A. Andersen},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 10},
  pages={3989-95}
}
Many strains of Chlamydia suis, a pathogen of pigs, express a stable tetracycline resistance phenotype. We demonstrate that this resistance pattern is associated with a resistance gene, tet(C), in the chlamydial chromosome. Four related genomic islands were identified in seven tetracycline-resistant C. suis strains. All resistant isolates carry the structural gene tet(C) and the tetracycline repressor gene tetR(C). The islands share significant nucleotide sequence identity with resistance… CONTINUE READING

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