Tetracycline resistance determinants in Mycobacterium and Streptomyces species.

  title={Tetracycline resistance determinants in Mycobacterium and Streptomyces species.},
  author={Yao-shan Pang and Barbara A Brown and Vincent A. Steingrube and Richard J. Wallace and Marilyn Roberts},
  journal={Antimicrobial agents and chemotherapy},
  volume={38 6},
Two of seven tetracycline-resistant (Tcr) Mycobacterium fortuitum group isolates and six Tcr clinical Streptomyces isolates carried gram-positive Tcr determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the acquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species. 

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