Tetracycline-inducible packaging cell line for production of flavivirus replicon particles.

  title={Tetracycline-inducible packaging cell line for production of flavivirus replicon particles.},
  author={Tracey J. Harvey and Wen Jun Liu and Xiang Ju Wang and Richard Linedale and Michael Jacobs and Andrew J Davidson and Thuy Trong Le and Itaru Anraku and Andreas Suhrbier and Pei-Yong Shi and Alexander A Khromykh},
  journal={Journal of virology},
  volume={78 1},
We have previously developed replicon vectors derived from the Australian flavivirus Kunjin that have a unique noncytopathic nature and have been shown to direct prolonged high-level expression of encoded heterologous genes in vitro and in vivo and to induce strong and long-lasting immune responses to encoded immunogens in mice. To facilitate further applications of these vectors in the form of virus-like particles (VLPs), we have now generated a stable BHK packaging cell line, tetKUNCprME… CONTINUE READING
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