Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation.

@article{Tikka2001TetracyclineDA,
  title={Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation.},
  author={Tiina M. Tikka and Timo Usenius and Mikko J Tenhunen and Riitta Kein{\"a}nen and Jari Koistinaho},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 6},
  pages={1409-14}
}
DNA damage induced by low doses of ionizing radiation causes apoptosis, which is partially mediated via the generation of free radicals. Both free radicals and apoptosis are involved in the majority of brain diseases, including stroke, Alzheimer's disease and amyotrophic lateral sclerosis. Because previous studies have shown that tetracycline derivatives doxycycline and minocycline have anti-inflammatory effects and are protective against brain ischemia, we studied whether minocycline and… CONTINUE READING
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