Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.

@article{Chatzispyrou2015TetracyclineAI,
  title={Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.},
  author={Iliana A. Chatzispyrou and Ntsiki M. Held and Laurent Mouchiroud and Johan Auwerx and Riekelt H Houtkooper},
  journal={Cancer research},
  year={2015},
  volume={75 21},
  pages={4446-9}
}
Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "bacterial" ancestry, these antibiotics also target mitochondrial translation and impair mitochondrial function. Indeed, treatment with doxycycline-a tetracycline derivative-disturbs mitochondrial proteostasis and metabolic activity, and induces… CONTINUE READING
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