Tetracycline antibiotics and resistance mechanisms

  title={Tetracycline antibiotics and resistance mechanisms},
  author={Fabian Nguyen and Agata L. Starosta and Stefan Arenz and Daniel Sohmen and Alexandra D{\"o}nh{\"o}fer and Daniel N. Wilson},
  journal={Biological Chemistry},
  pages={559 - 575}
Abstract The ribosome and protein synthesis are major targets within the cell for inhibition by antibiotics, such as the tetracyclines. The tetracycline family of antibiotics represent a large and diverse group of compounds, ranging from the naturally produced chlortetracycline, introduced into medical usage in the 1940s, to second and third generation semi-synthetic derivatives of tetracycline, such as doxycycline, minocycline and more recently the glycylcycline tigecycline. Here we describe… 

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