Tetracycline Inhibits Local Inflammation Induced by Cerebral Ischemia via Modulating Autophagy

@inproceedings{Jiang2012TetracyclineIL,
  title={Tetracycline Inhibits Local Inflammation Induced by Cerebral Ischemia via Modulating Autophagy},
  author={Yongjun Jiang and Juehua Zhu and Li Wu and Gelin Xu and Jianwu Dai and Xinfeng Liu},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Tetracycline exerts neuroprotection via suppressing the local inflammation induced by cerebral ischemia. However, the underlying mechanism is not completely clear. METHODOLOGY/PRINCIPAL FINDINGS The mRNA and protein expressions of tumor necrosis factor α and interleukin 6 and the number of activated microglia were measured to detect the inflammatory process in the ischemic hemisphere. The key proteins of nuclear factor kappa B pathway and the binding activity of nuclear factor… CONTINUE READING

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