Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine.

  title={Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine.},
  author={T. Yoshioka and J. A. Krauser and F. Guengerich},
  journal={Chemical research in toxicology},
  volume={15 8},
  • T. Yoshioka, J. A. Krauser, F. Guengerich
  • Published 2002
  • Chemistry, Medicine
  • Chemical research in toxicology
  • Tetrachloroethylene, or perchloroethylene (PCE), has considerable industrial use and is of toxicological interest because of a variety of effects. Most of the existing literature presents PCE oxide as a critical intermediate in the oxidative metabolism of PCE to Cl(3)CCO(2)H, oxalic acid, and products covalently bound to proteins, including trichloroacetyl derivatives of lysine. PCE oxide was synthesized by photochemical oxidation of PCE and characterized. Decomposition at neutral pH (t(1/2… CONTINUE READING
    16 Citations
    Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions.
    • F. Guengerich
    • Chemistry, Medicine
    • Archives of biochemistry and biophysics
    • 2003
    • 158
    Biotransformation of trans-1,1,1,3-tetrafluoropropene (HFO-1234ze).
    • 15
    • PDF
    Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues
    • 32
    • PDF
    Cytochrome P450s and other enzymes in drug metabolism and toxicity
    • 492
    • PDF