Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.

Abstract

Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic potential. The most widely employed CK2 inhibitor is 4,5,6,7-tetrabromobenzotriazole (TBB), which exhibits a comparable efficacy toward another kinase, DYRK1 a. Here we describe the development of a new… (More)

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Cite this paper

@article{Pagano2007TetrabromocinnamicA, title={Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.}, author={Mario Pagano and Giorgia Poletto and Giovanni di Maira and Giorgio Cozza and Maria Angela Martins Ruzzene and Stefania Sarno and Jenny Bain and Matthew Elliott and Stefano Moro and Giuseppe Zagotto and Flavio Meggio and Lorenzo A Pinna}, journal={Chembiochem : a European journal of chemical biology}, year={2007}, volume={8 1}, pages={129-39} }