Tetra-arsenic oxide (Tetras) enhances radiation sensitivity of solid tumors by anti-vascular effect.


Tetras (tetra-arsenic oxide, As(4)O(6)) is a derivative of arsenic used in Korean traditional medicine for the treatment of cancer, but its mechanism remains largely undefined. Recently, a similar arsenic derivative, diarsenic trioxide (As(2)O(3), ATO), has been shown to mediate anti-tumor activity, therefore reigniting interest in the therapeutic effect of arsenic compounds. Here we report that Tetras can effectively mediate an anti-vascular effect on tumors, leading to delay in tumor growth and increased survival. Our study demonstrates for the first time the potential use of Tetras as a radiation therapy enhancement agent for solid tumors. These findings reveal an unappreciated role of Tetras in cancer therapy and its potential application to radiotherapy in achieving local tumor control.

DOI: 10.1016/j.canlet.2008.12.012

Cite this paper

@article{Park2009TetraarsenicO, title={Tetra-arsenic oxide (Tetras) enhances radiation sensitivity of solid tumors by anti-vascular effect.}, author={Sae-Gwang Park and J Jung and Hae Jeong Won and Mi Seon Kang and Su-Kil Seo and I. P. Choi and Choong Ki Eun and Ki Jung Ahn and Cheol Woo Park and Soo-Woong Lee and Young S. Lew and Ill-Ju Bae and In-Hak Choi}, journal={Cancer letters}, year={2009}, volume={277 2}, pages={212-7} }