Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast

@inproceedings{Liu2016TetheringTT,
  title={Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast},
  author={Jun Liu and Ming-Hong He and Jing Peng and Yi-Min Duan and Yi-Si Lu and Zhenfang Wu and Ting Gong and Hongjun Li and Jin-Qiu Zhou},
  booktitle={Aging},
  year={2016}
}
Chronological aging of the yeast Saccharomyces cerevisiae is attributed to multi-faceted traits especially those involving genome instability, and has been considered to be an aging model for post-mitotic cells in higher organisms. Telomeres are the physical ends of eukaryotic chromosomes, and are essential for genome integrity and stability. It remains elusive whether dysregulated telomerase activity affects chronological aging. We employed the CDC13-EST2 fusion gene, which tethers telomerase… CONTINUE READING
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