Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast.


The decay of eukaryotic mRNA is triggered mainly by deadenylation, which leads to decapping and degradation from the 5' end of an mRNA. Poly(A)-binding protein has been proposed to inhibit the decapping process and to stabilize mRNA by blocking the recruitment of mRNA to the P-bodies where mRNA degradation takes place after stimulation of translation… (More)
DOI: 10.1074/jbc.M110.117150

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