Tethering complexes in the endocytic pathway: CORVET and HOPS.

@article{Solinger2013TetheringCI,
  title={Tethering complexes in the endocytic pathway: CORVET and HOPS.},
  author={Jachen A. Solinger and Anne Spang},
  journal={The FEBS journal},
  year={2013},
  volume={280 12},
  pages={
          2743-57
        }
}
Endocytosis describes the processes by which proteins, peptides and solutes, and also pathogens, enter the cell. Endocytosed material progresses to endosomes. Genetic studies in yeast, worms, flies and mammals have identified a set of universally conserved proteins that are essential for early-to-late endosome transition and lysosome biogenesis, and for endolysosomal trafficking pathways, including autophagy. The two Vps-C complexes CORVET (class C core vacuole/endosome tethering) and HOPS… CONTINUE READING
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