Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.

@article{Jin2017TetherinST,
  title={Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.},
  author={Shouheng Jin and Shuo Tian and M. G. Luo and Weihong Xie and Tao Liu and Tianhao Duan and Yaoxing Wu and Jun Cui},
  journal={Molecular cell},
  year={2017},
  volume={68 2},
  pages={308-322.e4}
}
Tetherin (BST2/CD317) is an interferon-inducible antiviral factor known for its ability to block the release of enveloped viruses from infected cells. Yet its role in type I interferon (IFN) signaling remains poorly defined. Here, we demonstrate that Tetherin is a negative regulator of RIG-I like receptor (RLR)-mediated type I IFN signaling by targeting MAVS. The induction of Tetherin by type I IFN accelerates MAVS degradation via ubiquitin-dependent selective autophagy in human cells. Moreover… CONTINUE READING