Tetanus toxin fragment C-specific priming by intranasal infection with recombinant Bordetella pertussis.

@article{Reveneau2001TetanusTF,
  title={Tetanus toxin fragment C-specific priming by intranasal infection with recombinant Bordetella pertussis.},
  author={Nathalie Reveneau and S. Miguel Alonso and Françoise Jacob-Dubuisson and Annick Mercenier and Camille Locht},
  journal={Vaccine},
  year={2001},
  volume={20 5-6},
  pages={926-33}
}
As an alternative to parenteral administration, mucosal administration offers several advantages including the ease of administration, safety and the ability to induce mucosal immunity. As a first step towards nasal administration of important childhood vaccines, we have previously developed attenuated Bordetella pertussis strains able to protect mice against pertussis upon nasal vaccination. Since pertussis vaccines are generally combined with tetanus and diphtheria vaccines, we constructed… CONTINUE READING