Tetanus toxin fragment C-specific priming by intranasal infection with recombinant Bordetella pertussis.


As an alternative to parenteral administration, mucosal administration offers several advantages including the ease of administration, safety and the ability to induce mucosal immunity. As a first step towards nasal administration of important childhood vaccines, we have previously developed attenuated Bordetella pertussis strains able to protect mice… (More)


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