Tetanus toxin: a rapid and selective blockade of the calcium, but not sodium, component of action potentials in cultured neuroblastoma N1E-115 cells

@article{Higashida1983TetanusTA,
  title={Tetanus toxin: a rapid and selective blockade of the calcium, but not sodium, component of action potentials in cultured neuroblastoma N1E-115 cells},
  author={Haruhiro Higashida and Nakaba Sugimoto and Kunihiro Ozutsumi and Naomasa Miki and Morihiro Matsuda},
  journal={Brain Research},
  year={1983},
  volume={279},
  pages={363-368}
}
The slow action potential of mouse neuroblastoma N1E-115 cells, which was elicited in Na-free medium and whose amplitude was directly dependent on extracellular Ca concentrations, was blocked by tetanus toxin (TNTX) without change in resting membrane potential and resistance. The average value of action potential overshoot (peak potential level of spikes) in the absence and presence of TNTX was -1 and -11 mV, respectively. The concentration of TNTX required for 50% inhibition of Ca-dependent… CONTINUE READING
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