Tetanus Toxin C-Fragment: The Courier and the Cure?

  title={Tetanus Toxin C-Fragment: The Courier and the Cure?},
  author={Janne M. Toivonen and Sara Oliv{\'a}n and Rosario Osta},
In many neurological disorders strategies for a specific delivery of a biological activity from the periphery to the central nervous system (CNS) remains a considerable challenge for successful therapy. Reporter assays have established that the non-toxic C-fragment of tetanus toxin (TTC), provided either as protein or encoded by non-viral naked DNA plasmid, binds pre-synaptic motor neuron terminals and can facilitate the retrograde axonal transport of desired therapeutic molecules to the CNS… CONTINUE READING

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