Tetanic fade during neuromuscular blockade produced by atracurium in the rat diaphragm preparation.

In the present investigation, we studied and measured the phenomenon of tetanic fade and peak tetanic tension depression in the rat diaphragm preparation in the presence of a blocking concentration of atracurium (e.g., 10 mumol.l-1). Atracurium (10 mumol.l-1) produced a pronounced tetanic fade (i.e., 47-69% reduction of total sustained tetanic tension) at a… (More)