Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

  title={Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.},
  author={Kelly Moran-Crusio and Linsey Reavie and Alan Shih and O. A. L. Abdel-Wahab and Delphine Ndiaye-Lobry and Camille Lobry and Maria Eugenia Figueroa and Aparna Vasanthakumar and Jay Patel and Xinyang Zhao and Fabiana Perna and Suveg Pandey and Jozef Madzo and Chun-Xiao Song and Qing Dai and Chuan He and S. Eldurssi Ibrahim and Miloslav E Beran and Jiri Zavadil and Stephen Nimer and Ari Melnick and Lucy A Godley and Iannis Aifantis and Ross L. Levine},
  journal={Cancer cell},
  volume={20 1},
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not been delineated. We report here an animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by… CONTINUE READING
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