Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

  title={Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6},
  author={Qian Zhang and Kai Zhao and Qicong Shen and Yanmei Han and Yan Gu and Xia Chong Li and Dezhi Zhao and Yiqi Liu and Chunmei Wang and Xiang Zhang and Xiaoping Su and Juan Liu and Wei Ge and Ross L. Levine and Nan Li and Xuetao Cao},
Epigenetic modifiers have fundamental roles in defining unique cellular identity through the establishment and maintenance of lineage-specific chromatin and methylation status. Several DNA modifications such as 5-hydroxymethylcytosine (5hmC) are catalysed by the ten eleven translocation (Tet) methylcytosine dioxygenase family members, and the roles of Tet proteins in regulating chromatin architecture and gene transcription independently of DNA methylation have been gradually uncovered. However… CONTINUE READING
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