Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

@article{Zhang2015Tet2IR,
  title={Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6},
  author={Q. Zhang and K. Zhao and Qicong Shen and Y. Han and Yan Gu and Xia Li and D. Zhao and Yiqi Liu and C. Wang and X. Zhang and X. Su and J. Liu and W. Ge and R. Levine and N. Li and X. Cao},
  journal={Nature},
  year={2015},
  volume={525},
  pages={389-393}
}
  • Q. Zhang, K. Zhao, +13 authors X. Cao
  • Published 2015
  • Medicine, Biology
  • Nature
  • Epigenetic modifiers have fundamental roles in defining unique cellular identity through the establishment and maintenance of lineage-specific chromatin and methylation status. Several DNA modifications such as 5-hydroxymethylcytosine (5hmC) are catalysed by the ten eleven translocation (Tet) methylcytosine dioxygenase family members, and the roles of Tet proteins in regulating chromatin architecture and gene transcription independently of DNA methylation have been gradually uncovered. However… CONTINUE READING

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