Tet family of 5-methylcytosine dioxygenases in mammalian development

  title={Tet family of 5-methylcytosine dioxygenases in mammalian development},
  author={Hongbo Zhao and Taiping Chen},
  journal={Journal of Human Genetics},
Methylation of cytosines is a major epigenetic modification in mammalian genomes. The levels and patterns of DNA methylation are the results of the opposing actions of methylating and demethylating machineries. Over the past two decades, great progress has been made in elucidating the methylating machinery including the identification and functional characterization of the DNA methyltransferases (Dnmts). However, the mechanisms of demethylation and the major players involved had been elusive. A… CONTINUE READING