Tests for genetic linkage and homogeneity.

@article{Lemdani1995TestsFG,
  title={Tests for genetic linkage and homogeneity.},
  author={M. Lemdani and O. Pons},
  journal={Biometrics},
  year={1995},
  volume={51 3},
  pages={
          1033-41
        }
}
This report concerns likelihood ratio tests in a heterogeneous model for linkage, where the recombination fraction has a binomial mixture distribution with an unknown proportion of unlinked families. We consider families of unequal sizes with known or unknown phase data. In both cases, the limit distributions of the linkage test statistics are a mixture of a mass at ) and of a X2/1 distribution in equal proportions and homogeneity test statistics tend to the supremum of Gaussian processes. The… Expand
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References

SHOWING 1-10 OF 11 REFERENCES
A new statistical test for linkage heterogeneity.
  • N. Risch
  • Mathematics, Medicine
  • American journal of human genetics
  • 1988
  • 56
Testing for heterogeneity of recombination fraction values in Human Genetics
  • C. Smith
  • Biology, Medicine
  • Annals of human genetics
  • 1963
  • 280
Distribution of the admixture test for the detection of linkage under heterogeneity
  • J. Faraway
  • Mathematics, Medicine
  • Genetic epidemiology
  • 1993
  • 69
  • PDF
Statistical testing of genetic linkage under heterogeneity.
  • 26
Analysis of Human Genetic Linkage
  • 1,278
  • PDF
STOCHASTIC ESTIMATION AND TESTING
  • 29
...
1
2
...