Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort

@inproceedings{Malzahn2009TestsFC,
  title={Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort},
  author={Doerthe Malzahn and Yesilda Balavarca and Jingky Pamesa Lozano and H. Bickeb{\"o}ller},
  booktitle={BMC proceedings},
  year={2009}
}
For the Framingham Heart Study (FHS) and simulated FHS (FHSsim) data, we tested for gene-gene interaction in quantitative traits employing a longitudinal nonparametric association test (LNPT) and, for comparison, a survival analysis. We report results for the Offspring Cohort by LNPT analysis and on all longitudinal cohorts by survival analysis with cohort effect adjustment. We verified that type I errors were not inflated. We compared the power of both methods to detect in FHSsim data two sets… CONTINUE READING