Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages.

@article{Langer2002TestosteroneUS,
  title={Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages.},
  author={Claus Langer and Barbara Gansz and Christian Goepfert and Thomas Engel and Yoshinari Uehara and Gerlinde von Dehn and Hans Christian Jansen and G. A{\ss}mann and Arnold von Eckardstein},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={296 5},
  pages={
          1051-7
        }
}
By lowering high density lipoprotein (HDL) cholesterol, testosterone contributes to the gender difference in HDL cholesterol and has been accused to be pro-atherogenic. The mechanism by which testosterone influences HDL cholesterol is little understood. We therefore investigated the effect of testosterone on the gene expression of apolipoprotein A-I (apoA-I), hepatic lipase (HL), scavenger receptor B1 (SR-BI), and the ATP binding cassette transporter A1 (ABCA1), all of which are important… CONTINUE READING
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