Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss

@article{Yassin2013TestosteroneTI,
  title={Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss},
  author={A. Yassin and Gheorge Doros},
  journal={Clinical Obesity},
  year={2013},
  volume={3},
  pages={73 - 83}
}
Hypogonadism is associated with increased fat mass and reduced muscle mass, which contributes to obesity and health risks, such as cardiovascular disease. Testosterone treatment of hypogonadal men improves muscle mass and reduces fat mass; however, many of these studies are of short duration. Thus, the long‐term effects of testosterone on body anthropometry are not known. 
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Even when controlling for improved BMI, pre-treatment A1C, and age, testosterone positively impacted glycemic control in diabetes patients with hypogonadism, with the most benefit noted in those most adherent to therapy (>75%).
Metabolic syndrome and hypogonadism--two peas in a pod.
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An account of the pathophysiological mechanisms in the bidirectional relationship between hypogonadism and body composition, inflammation and insulin sensitivity as well as the effects of testosterone replacement on diverse metabolic parameters are provided.
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TLDR
Study showed favorable effects of testosterone replacement in aging patients with low testosterone levels, and improves cardio-metabolic and hormonal parameters, and has a positive impact on patient body weight, favorable safety profile and high level of patient tolerability.
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  • A. Traish
  • Medicine
    Current opinion in endocrinology, diabetes, and obesity
  • 2014
TLDR
Analysis of contemporary data linking testosterone therapy in overweight and obese men with testosterone deficiency to increased lean body mass, decreased fat mass, improvement in overall body composition and sustained weight loss shows that testosterone therapy ameliorates components of the metabolic syndrome.
Long-term testosterone treatment in elderly men with hypogonadism and erectile dysfunction reduces obesity parameters and improves metabolic syndrome and health-related quality of life.
TLDR
Long-term TU treatment resulted in a sustained improvement in erectile function and muscle and joint pain, which contributed to an improvement in long-term health-related quality of life.
Secondary male hypogonadism: a prevalent but overlooked comorbidity of obesity
TLDR
Weight loss and treatment to replace testosterone levels improve the metabolic profile and quality of life in patients with obesity and hypogonadism; these beneficial effects depend on treatment modality and duration of therapy.
Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy
TLDR
Three factors were significantly associated with sustained weight loss over the entire period of TU treatment: a loss of 3% of the baseline body weight after 1 year of TRT, baseline BMI over 30 and a waist circumference >102 cm.
[Testosterone deficiency, metabolic syndrome and diabetes mellitus].
TLDR
Testosterone replacement therapy in patients with testosterone deficiency and type 2 diabetes mellitus and/or metabolic syndrome has shown reductions in insulin resistance, total cholesterol, LDL cholesterol and triglycerides and improvement in glycemic control and anthropometric parameters.
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