Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to <ce:italic>Plasmodium chabaudi</ce:italic> malaria

@article{Deli2011TestosteroneRO,
  title={Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to <ce:italic>Plasmodium chabaudi</ce:italic> malaria},
  author={Denis Deli{\'c} and Heidren Ellinger-Ziegelbauer and Hans Werner Vohr and Mohamed Dkhil and F. Wunderlich},
  journal={Steroids},
  year={2011},
  volume={76},
  pages={1204-1212}
}
Blood-stage malaria of Plasmodium chabaudi is characterized by its responsiveness to testosterone (T): T suppresses development of protective immunity, whereas once acquired immunity is T-unresponsive. Here, we have analyzed the liver, a T target and lymphoid organ with anti-malaria activity, for its T-responsiveness of gene expression in immune mice. Using Affymetrix microarray technology, in combination with quantitative RT-PCR, we have identified (i) T-unresponsive expression of newly… CONTINUE READING
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