Testosterone replacement therapy in older adult men.

  title={Testosterone replacement therapy in older adult men.},
  author={Joyce L Tenover},
  journal={International journal of andrology},
  volume={22 5},
  • J. Tenover
  • Published 1 October 1999
  • Medicine
  • International journal of andrology
Serum testosterone levels decline slowly with normal ageing in men and, although all men are not destined to become hypogonadal as they age, the prevalence of androgen deficiency in the older male is not insignificant. Over the past several decades, there has been an increasing interest in evaluating whether testosterone therapy (male HRT) might be beneficial for certain older men in preventing or reversing some aspects of ageing. The major androgen target organs of interest with regard to… 
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oday, it is generally recognized that there is a significant age-associated decrease in bioactive testosterone levels in men beginning in their middle-age years. At age 75, mean plasma testosterone
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    The Journal of clinical endocrinology and metabolism
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Short term TE supplementation to healthy older men who have serum T levels near or below the lower limit of normal for young adult men results in an increase in lean body mass and possibly a decline in bone resorption, as assessed by urinary hydroxyproline excretion, with some effect on serum lipoproteins, hematological parameters, and PSA.
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  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 1991
Clinical signs of old age in men is accompanied by clinical signs, such as a decrease in muscle and bone mass, decrease in sexual hair growth, and decreased libido and sexual activity, suggesting decreased virility, supported by histological evidence for a decreased Leydig mass and function.
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