Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion.

@article{Fijak2011TestosteroneRE,
  title={Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion.},
  author={Monika Fijak and Eva Schneider and J. M. Klug and Sudhanshu Bhushan and H Hackstein and Gerhard Schuler and Malgorzata Wygrecka and Joerg Gromoll and Andreas Meinhardt},
  journal={Journal of immunology},
  year={2011},
  volume={186 9},
  pages={5162-72}
}
Despite the immune-privileged status of the male genital tract, infection and inflammation of the male genital tract are important etiological factors in male infertility. A common observation in clinical and experimental orchitis as well as in systemic infection and inflammation are decreased levels of testosterone. Emerging data point to an immunosuppressive role of testosterone. In our study, we substituted testosterone levels in experimental autoimmune orchitis (EAO) in rat by s.c… CONTINUE READING

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