Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.

  title={Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.},
  author={James A. White and Song Gao and Melissa J. Puppa and Shuichi Sato and Stephen Welle and James A Carson},
  journal={Molecular and cellular endocrinology},
  volume={365 2},
Low endogenous testosterone production, known as hypogonadism is commonly associated with conditions inducing muscle wasting. Akt signaling can control skeletal muscle mass through mTOR regulation of protein synthesis and FoxO regulation of protein degradation, and this pathway has been previously identified as a target of androgen signaling. However, the testosterone sensitivity of Akt/mTOR signaling requires further understanding in order to grasp the significance of varied testosterone… CONTINUE READING