Testosterone regulates pyruvate dehydrogenase activity of prostate mitochondria.

  title={Testosterone regulates pyruvate dehydrogenase activity of prostate mitochondria.},
  author={Leslie C. Costello and Renty B. Franklin},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={25 5},
A major and unique function of the prostate is the production of extremely high levels of citrate. Testosterone is an important regulator of this function. This regulation is achieved by hormonal stimulation of citrate synthesis by prostate secretory epithelial cells. Previous studies have established that testosterone stimulates the mitochondrial transamination of aspartate to OAA for citrate synthesis. However, increased citrate synthesis would also require an increased availability of AcCoA… CONTINUE READING