Testosterone regulates cardiac contractile activation by modulating SERCA but not NCX activity.

@article{Witayavanitkul2013TestosteroneRC,
  title={Testosterone regulates cardiac contractile activation by modulating SERCA but not NCX activity.},
  author={Namthip Witayavanitkul and Warunya Woranush and Tepmanas Bupha-Intr and Jonggonnee Wattanapermpool},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 3},
  pages={H465-72}
}
Alterations in intracellular Ca(2+) transients of cardiomyocytes in orchidectomized (ORX) rats could be a cause of cardiac dysfunction in the hypogonadal condition. To investigate the role of male sex hormones in intracellular Ca(2+) homeostasis during relaxation, Ca(2+)-handling activities by sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) and the Na(+)/Ca(2+) exchanger (NCX) were evaluated in the ventricular muscle of 10-wk-old ORX rats with and without testosterone supplementation (2.5 mg… CONTINUE READING