Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function.

@article{Ba2000TestosteroneRB,
  title={Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function.},
  author={Zheng F. Ba and Ping Wang and Douglas J Koo and Ming-Sheng Zhou and William G. Cioffi and Kirby I. Bland and Irshad H. Chaudry},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={279 5},
  pages={R1841-8}
}
Although the testosterone receptor antagonist flutamide restores the depressed immune function in males after trauma and hemorrhage, it remains unknown whether this agent has any salutary effects on adrenal function. To study this, male rats underwent laparotomy and were bled to and maintained at a blood pressure of 40 mmHg until 40% of the shed blood volume was returned in the form of Ringer lactate. Animals were then resuscitated and flutamide (25 mg/kg body wt) was administered… CONTINUE READING
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