Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol

@article{Reddy2004TestosteroneMO,
  title={Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol},
  author={D. Reddy},
  journal={Neuroscience},
  year={2004},
  volume={129},
  pages={195-207}
}
  • D. Reddy
  • Published 2004
  • Chemistry
  • Neuroscience
  • Abstract Testosterone modulates seizure susceptibility in animals and humans, but the underlying mechanisms are obscure. Here, testosterone modulation of seizure susceptibility is hypothesized to occur through its conversion to neurosteroids with “anticonvulsant” and “proconvulsant” actions, and hence the net effect of testosterone on neural excitability and seizure activity depends on the levels of distinct testosterone metabolites. Testosterone undergoes metabolism to neurosteroids via two… CONTINUE READING
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