• DOI:10.1016/j.neuroscience.2004.08.002
Corpus ID: 54391883

Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol

@article{Reddy2004TestosteroneMO,
  title={Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol},
  author={D. Reddy},
  journal={Neuroscience},
  year={2004},
  volume={129},
  pages={195-207}
}

D. Reddy

Published 2004

Biology

Neuroscience

Abstract Testosterone modulates seizure susceptibility in animals and humans, but the underlying mechanisms are obscure. Here, testosterone modulation of seizure susceptibility is hypothesized to occur through its conversion to neurosteroids with “anticonvulsant” and “proconvulsant” actions, and hence the net effect of testosterone on neural excitability and seizure activity depends on the levels of distinct testosterone metabolites. Testosterone undergoes metabolism to neurosteroids via two… CONTINUE READING

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