Testosterone modulation of cardiac β-adrenergic signals in a rat model of heart failure.

@article{Sun2011TestosteroneMO,
  title={Testosterone modulation of cardiac β-adrenergic signals in a rat model of heart failure.},
  author={Junfeng Sun and Lu Fu and Xianling Tang and Ying Han and Dan Ma and Junxian Cao and Ningning Kang and Hongfei Ji},
  journal={General and comparative endocrinology},
  year={2011},
  volume={172 3},
  pages={518-25}
}
In this study, we examined the effects of castration and testosterone replacement on β-adrenoceptor and G protein expression in rats subjected to doxorubicin-induced heart failure. Five groups were included in this report: control, sham-castration with heart failure, castration with heart failure, castration+testosterone replacement with heart failure and castration+testosterone replacement and flutamide with heart failure. At 4 weeks post-treatment, echocardiography, hemodynamics and… CONTINUE READING

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