Testosterone is required for delayed cardioprotection and enhanced heat shock protein 70 expression induced by preconditioning.

@article{Liu2006TestosteroneIR,
  title={Testosterone is required for delayed cardioprotection and enhanced heat shock protein 70 expression induced by preconditioning.},
  author={Jing Liu and S. Tsang and Tak Wong},
  journal={Endocrinology},
  year={2006},
  volume={147 10},
  pages={4569-77}
}
Ischemic preconditioning fails to confer immediate cardioprotection in the absence of testosterone, indicating that the hormone is required for the process. Here we set out to determine whether testosterone is also necessary for delayed cardioprotection and, if so, how it acts. Male Sprague Dawley rats (7-8 wk) underwent sham operation or gonadectomy without (G) or with testosterone replacement (GT) for 8 wk. Isolated ventricular myocytes were preconditioned either by metabolic inhibition or… CONTINUE READING

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