Testosterone inhibits facilitating effects of parenting experience on parental behavior and the oxytocin neural system in mice

@article{Okabe2013TestosteroneIF,
  title={Testosterone inhibits facilitating effects of parenting experience on parental behavior and the oxytocin neural system in mice},
  author={Shota Okabe and Kanako Kitano and Miho Nagasawa and K. Mogi and T. Kikusui},
  journal={Physiology \& Behavior},
  year={2013},
  volume={118},
  pages={159-164}
}
Parental behavior in mammals is facilitated by sensory experiences from infant, and by endocrine hormones. However, the interactions between these factors in the parental behavior of nonreproductive adults are not understood. We examined the interactive effects of gonadal hormones and the experience of repeated pup exposure on parental behavior in sexually naive mice. We also compared oxytocin (OT) expression levels in the paraventricular nucleus of the hypothalamus to behavioral outcomes… Expand
Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice
TLDR
Investigation of the role of OT for facilitating effects of adult-pup interactions on alloparental behavior via neural activity of preoptic area (POA), including MPOA and adjacent area demonstrated that the facilitated effects of repeated pup Exposure occurred via an organizational role of the OT system. Expand
Paternal Care Impacts Oxytocin Expression in California Mouse Offspring and Basal Testosterone in Female, but Not Male Pups
TLDR
Using the bi-parental California mouse, it is demonstrated that parenting and aggression are programmed, at least in part, by paternal behavior as adult offspring model the degree of parental behavior received in development and are more territorial following high as compared to low levels of care. Expand
Effects of neonatal oxytocin manipulation on development of social behaviors in mice
TLDR
Results suggested that neonatal OT action may positively regulate alloparental responsiveness in adulthood, considering that the organizational effects of OT have also been shown in voles and rats. Expand
Gonadectomy prior to puberty decreases normal parental behavior in adult mice
TLDR
The absence of gonads and thereby the absence of appropriate gonadal steroid hormones during puberty/adolescence may have a profound effect on pup directed parental behaviors in adult mice. Expand
Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in Mouse Sires that Engage in Communicative Interactions with Pairmates
TLDR
It is suggested that brain aromatization regulates the initiation, development, and maintenance of paternal behavior in the ICR male mice. Expand
Testosterone, oxytocin, and the development of human parental care
TLDR
The first to test the interaction of OT and T in relation to observed maternal behavior, underscores the need for much further research on the complex bidirectional effects of steroid and neuropeptide systems on human mothering and fathering. Expand
The blockade of oxytocin receptors in the paraventricular thalamus reduces maternal crouching behavior over pups in lactating mice
TLDR
Findings suggest that OTR-expressing neurons in the paraventricular thalamus of lactating dams are involved in maternal crouching behavior. Expand
Vasopressin, but not oxytocin, modulates responses to infant stimuli in marmosets providing care to dependent infants.
TLDR
In all classes of marmoset caregivers, vasopressin enhances responsiveness to infant-associated stimuli in caregivers during periods in which infant care is most crucial, and marmosets treated with vasopressed showed enhanced responsiveness to newborn stimuli only when caring for infants. Expand
Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women
TLDR
This study provides the first evidence that oxytocin influences endogenous testosterone levels in autistic individuals, with autistic women showing increases similar to previous reports of neurotypical men. Expand
Salivary sex hormone levels following oxytocin administration in autistic and typical women
TLDR
Assessment of salivary testosterone and oestradiol levels in 16 autistic and 29 typical women before and after intranasal administration of 24IU oxytocin or placebo provides further evidence that oxytoc in influences endogenous testosterone, with autistic women showing increases similar to previous reports in typical men. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 23 REFERENCES
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
TLDR
It is suggested that maternal licking/grooming influences the development of estrogen sensitivity in brain regions that regulate maternal behavior, providing a potential mechanism for the intergenerational transmission of individual differences in maternal behavior. Expand
The Effects of Social Experience and Gonadal Hormones on Retrieving Behavior of Mice and their Responses to Pup Ultrasonic Vocalizations
TLDR
The results suggest that not only parenting experience, but also mating experience, may enhance retrieving activity and response to pup USVs in mice of both sexes, although the degree to which parenting experience contributed to the enhancement of both activities differed between the sexes. Expand
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin.
  • C. Pedersen, A. Prange
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1979
TLDR
Elevated or recently elevated levels of estrogen may be necessary for the induction of full maternal behavior by oxytocin, functions related to parturition and nuturing in virgin female rats. Expand
Sex Differences in Behavioral and Corticosterone Responses to Mild Stressors in ICR Mice are Altered by Ovariectomy in Peripubertal Period
TLDR
The results suggest that the sex difference in novelty exposure observed in the form of a greater hypothalamic-pituitary-adrenal (HPA) axis response in female ICR mice is controlled by ovary-derived factors in adults. Expand
Gonadal Steroids have Paradoxical Effects on Brain Oxytocin Receptors
TLDR
The results suggest that the brain oxytocin receptor varies across species not only in its distribution but also in its regional regulation by gonadal steroids. Expand
Estradiol and parental experience, but not prolactin are necessary for ultrasound recognition and pup-retrieving in the mouse
TLDR
Prolactin is dispensable for maintaining maternal pup-retrieving and ultrasound recognition and the process of achieving pup-experience is enhanced by the presence of estradiol. Expand
Oxytocin and the Development of Parenting in Humans
TLDR
Results are the first to describe plasma OT levels in new fathers and mothers across the transition to parenthood in relation to maternal and paternal typical parenting behaviors and may provide a normative basis for the study of parenting under conditions of high risk. Expand
Steroidal influences on pup-killing behavior in mice
  • B. Svare
  • Medicine, Chemistry
  • Hormones and Behavior
  • 1979
TLDR
It is suggested that both aromatization and reduction may be important for the stimulation of pup-killing behavior in mice. Expand
Sex differences in the parental behavior of rodents
TLDR
The literature on similarities and/or differences between male and female laboratory rodents in their parental responsiveness is reviewed and how the parental behavior of males and females is influenced by hormones, developmental processes, and prior social experiences is discussed. Expand
Oxytocin, But Not Oxytocin Receptor, is Regulated by Oestrogen Receptor β in the Female Mouse Hypothalamus
TLDR
It is suggested that ERβ is necessary for the regulation of the expression of oxytocin in the PVN, and region and peptide specific regulation by ERα and ERβ in the mouse hypothalamus is shown. Expand
...
1
2
3
...