Testosterone inhibits estrogen‐induced mammary epithelial proliferation and suppresses estrogen receptor expression

@article{Zhou2000TestosteroneIE,
  title={Testosterone inhibits estrogen‐induced mammary epithelial proliferation and suppresses estrogen receptor expression},
  author={J. Zhou and S. Ng and O. Adesanya-Famuiya and K. Anderson and C. Bondy},
  journal={The FASEB Journal},
  year={2000},
  volume={14},
  pages={1725 - 1730}
}
  • J. Zhou, S. Ng, +2 authors C. Bondy
  • Published 2000
  • Medicine, Biology
  • The FASEB Journal
  • This study investigated the effect of sex steroids and tamoxifen on primate mammary epithelial proliferation and steroid receptor gene expression. Ovariectomized rhesus monkeys were treated with placebo, 17β estradiol (E2) alone or in combination with progesterone (E2/P) or testosterone (E2/T), or tamoxifen for 3 days. E2 alone increased mammary epithelial proliferation by ~sixfold (P<0.0001) and increased mammary epithelial estrogen receptor (ERα) mRNA expression by ~50% (P<0.0001; ERβ mRNA… CONTINUE READING
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