Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis.

@article{Yang2010TestosteroneIR,
  title={Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis.},
  author={Jun-Ling Yang and Chun-Ping Zhang and Lei Li and Lin Huang and Shao-Yang Ji and Cui-ling Lu and Cui-hong Fan and Huan Cai and Yu Hu Ren and Z T Hu and Fei Gao and Yi-Xun Liu},
  journal={Endocrinology},
  year={2010},
  volume={151 2},
  pages={774-82}
}
Increasing evidence has shown that excess androgen may be a main cause of polycystic ovary syndrome (PCOS). However, the molecular mechanism of androgen action on the ovary is unclear. To investigate the possible impacts of androgen on early follicular development, neonatal mouse ovaries mainly containing primordial follicles were cultured with testosterone. We demonstrated that the number of primary follicles was increased after 10 d culture with testosterone treatment via phosphatidylinositol… CONTINUE READING
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