Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy.

@article{SinhaHikim2002TestosteroneinducedII,
  title={Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy.},
  author={Indrani Sinha-Hikim and Jorge N. Artaza and Linda J. Woodhouse and N{\'e}stor F. Gonz{\'a}lez-Cadavid and Atam B. Singh and Martin I Lee and Thomas W Storer and Richard Casaburi and Ruoquing Shen and Shalender Bhasin},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 1},
  pages={
          E154-64
        }
}
Administration of replacement doses of testosterone to healthy hypogonadal men and supraphysiological doses to eugonadal men increases muscle size. To determine whether testosterone-induced increase in muscle size is due to muscle fiber hypertrophy, 61 healthy men, 18-35 yr of age, received monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist to suppress endogenous testosterone secretion and weekly injections of 25, 50, 125, 300, or 600 mg testosterone enanthate (TE… 
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Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle.
TLDR
Older men are as responsive as young men to testosterone's anabolic effects; however, older men have lower testosterone clearance rates, higher increments in hemoglobin, and a higher frequency of adverse effects.
Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men.
TLDR
Older men respond to graded doses of testosterone with a dose-dependent increase in muscle fiber CSA and satellite cell number and testosterone-induced skeletal muscle hypertrophy in older men is associated with increased satellite cell replication and activation.
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.
TLDR
It is concluded that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes inatellite cell ultrastructure.
Risks and benefits of testosterone therapy in older men.
TLDR
A general policy of testosterone replacement in all older men with age-related decline in testosterone levels is not justified, because the clinical benefits and long-term risks of testosterone therapy have not been adequately assessed in large, randomized clinical trials involving older men (defined as age>65 years) with androgen deficiency.
Development of models to predict anabolic response to testosterone administration in healthy young men.
TLDR
The anabolic response of healthy, young men to exogenous testosterone administration can largely be predicted by the testosterone dose, thanks to univariate and multivariate analysis and cross-validation in data subsets.
Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration of young women.
TLDR
Novel insight is provided into fiber type-specific adaptations present already after 10 weeks of only moderately elevated testosterone levels in women, as well as how these adaptations can be achieved in skeletal muscle of young healthy, physically active women.
Androgen receptors and testosterone in men—Effects of protein ingestion, resistance exercise and fiber type
Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease.
TLDR
Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels.
Hypertrophy with unilateral resistance exercise occurs without increases in endogenous anabolic hormone concentration
TLDR
In conclusion, unilateral training induced local muscle hypertrophy only in the exercised limb, which occurred in the absence of changes in systemic hormones that ostensibly play a role in musclehypertrophy.
Weekly versus monthly testosterone administration on fast and slow skeletal muscle fibers in older adult males.
TLDR
T replacement effects were fiber-type dependent, restricted to increases in cell size, P0, and peak power, and dependent on the paradigm selected (WK vs MO).
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