Testosterone-independent down-regulation of Oct2 in the kidney medulla from a uranyl nitrate-induced rat model of acute renal failure: effects on distribution of a model organic cation, tetraethylammonium.

@article{Shim2009TestosteroneindependentDO,
  title={Testosterone-independent down-regulation of Oct2 in the kidney medulla from a uranyl nitrate-induced rat model of acute renal failure: effects on distribution of a model organic cation, tetraethylammonium.},
  author={Won-Sik Shim and Joo-Hyun Park and Sun-Joo Ahn and Liwei Han and Qing-Ri Jin and Hong Li and Min-Koo Choi and Dae-Duk Kim and Suk-Jae Chung and Chang-koo Shim},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 2},
  pages={739-47}
}
Although acute renal failure (ARF) has been an area of extensive research in recent decades, our understanding of ARF is far from complete. Organic cations (OCs) are primarily excreted via vectorial transport by various renal organic cation transporters (OCTs). It is reasonable to assume that ARF may alter the expression profiles of these transporters. In a rat ARF model, induction of ARF by uranyl nitrate (UN) treatment significantly decreased the levels of Oct2 (slc22a2) mRNA and protein in… CONTINUE READING

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