Testosterone has sublayer-specific effects on dendritic spine maturation mediated by BDNF and PSD-95 in pyramidal neurons in the hippocampus CA1 area.

@article{Li2012TestosteroneHS,
  title={Testosterone has sublayer-specific effects on dendritic spine maturation mediated by BDNF and PSD-95 in pyramidal neurons in the hippocampus CA1 area.},
  author={Meihua Li and M Masugi-Tokita and Keiko Takanami and Shunji Yamada and Mitsuhiro Kawata},
  journal={Brain research},
  year={2012},
  volume={1484},
  pages={76-84}
}
Testosterone has a number of important physiological roles and acts on peripheral target tissues and the central nervous system. Testosterone exerts many of its effects through the androgen receptor (AR). ARs are widely distributed in nervous tissues and particularly strongly expressed in hippocampal CA1 pyramidal neurons, which play critical roles in spatial memory tasks. Dendritic spines are specialized to receive synaptic inputs, and a change in spine morphology is correlated with the… CONTINUE READING
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