Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial.

@article{Pope2003TestosteroneGS,
  title={Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial.},
  author={Harrison Graham Pope and Geoffrey H. Cohane and Gen Kanayama and Arthur J. Siegel and James I. Hudson},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 1},
  pages={105-11}
}
OBJECTIVE Testosterone supplementation may produce antidepressant effects in men, but until recently it has required cumbersome parenteral administration. In an 8-week randomized, placebo-controlled trial, the authors administered a testosterone transdermal gel to men aged 30-65 who had refractory depression and low or borderline testosterone levels. METHOD Of 56 men screened, 24 (42.9%) displayed morning serum total testosterone levels of 350 ng/dl or less (normal range=270-1070). Of these… CONTINUE READING
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