Testosterone for peri- and postmenopausal women.

@article{Somboonporn2005TestosteroneFP,
  title={Testosterone for peri- and postmenopausal women.},
  author={Woraluk Somboonporn and Susan R. Davis and Mourad W. Seif and Robin J. Bell},
  journal={The Cochrane database of systematic reviews},
  year={2005},
  volume={4},
  pages={
          CD004509
        }
}
BACKGROUND : The value of adding testosterone to hormone therapy (HT) for the management of peri- and postmenopausal women is controversial and has not been systematically reviewed. OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy. SEARCH STRATEGY : We searched the Cochrane Menstrual Disorders and Subfertility Group Trials Register (1st November 2003), The Cochrane Library (Issue 2, 2003), MEDLINE (1966 to 1st… 
Clinical review: The benefits and harms of systemic testosterone therapy in postmenopausal women with normal adrenal function: a systematic review and meta-analysis.
TLDR
A systematic review and meta-analysis of randomized trials found that T use was associated with statistically significant improvement in various domains of sexual function and personal distress in postmenopausal women, although the majority of the trials did not have specific or contemporary diagnostic criteria for androgen deficiency in women.
Effects of testosterone therapy for women: a systematic review and meta-analysis protocol
TLDR
This comprehensive systematic review with meta-analysis will provide the foundation for the development of evidence-based clinical practice guidelines that will address benefits and risks of testosterone therapy, when treatment might be appropriate or inappropriate, areas of clinical uncertainty and the basis for assessment and monitoring of patients.
Androgen therapy in women, beyond libido
  • S. Davis
  • Medicine
    Climacteric : the journal of the International Menopause Society
  • 2013
TLDR
Issues that urgently need to be addressed include approval of a testosterone formulation that delivers a female dose such that physicians refrain from prescribing compounded testosterone or modifying doses of testosterone formulated for men and regulation of prescription of compounded androgens for women.
[The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review].
TLDR
At short-term, testosterone seems to improve sexual function in postmenopausal women, particularly sexual desire, but more studies with larger sample size and longer follow-up are needed to understand its long-term safety and effectiveness.
Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data.
TLDR
Testosterone is effective for postmenopausal women with low sexual desire causing distress, with administration via non-oral routes (eg, transdermal application) preferred because of a neutral lipid profile.
Testosterone therapy for postmenopausal women: efficacy and safety.
TLDR
Fair to good evidence exists that the use of testosterone in combination with hormone therapy has both benefits and risks; there has been insufficient reporting of other side effects; hence, testosterone therapy should be used with caution.
Emerging Role of Testosterone in Menopause
TLDR
The proposed benefits of the addition of exogenous testosterone to hormone therapy are the improvements in wellbeing, sexual function, unexplained fatigue, bone health, body composition and cognition.
Testosterone addition to estrogen therapy – Effects on inflammatory markers for cardiovascular disease
TLDR
Data suggest that testosterone addition to estrogen treatment in postmenopausal women has a modest influence on inflammatory markers and there were no apparent adverse effects.
Testosterone replacement therapy in naturally and surgically menopausal women.
TLDR
The balance of evidence seems to show that androgens have more of a positive effect than a negative effect in women if used properly, and the majority of available data suggests that testosterone replacement in women can be used safely without increased risk of endometrial or breast cancer.
Testosterone concentrations, using different assays, in different types of ovarian insufficiency: a systematic review and meta-analysis.
TLDR
It is demonstrated that total testosterone concentrations are decreased in women with spontaneous POI or iatrogenic menopause, and the potential implications of hypoandrogenism in these women remain to be elucidated.
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