Testosterone enhancement during pregnancy influences the 2D:4D ratio and open field motor activity of rat siblings in adulthood

@article{Talaroviov2009TestosteroneED,
  title={Testosterone enhancement during pregnancy influences the 2D:4D ratio and open field motor activity of rat siblings in adulthood},
  author={Al{\vz}beta Talarovi{\vc}ov{\'a} and Lucia Kr{\vs}kov{\'a} and Jana Bla{\vz}ekov{\'a}},
  journal={Hormones and Behavior},
  year={2009},
  volume={55},
  pages={235-239}
}
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121 Citations
Highly Influential Citations
4
Background Citations
36
Methods Citations
7
Results Citations
6

121 Citations

Does the 2nd and 4th digit ratio reflect prenatal androgen exposure?
TLDR
Prenatal hyperandrogenism leads to shorter lengths of 2D and 4D; however, it does not affect 2D:4D ratio; whether other steroid hormones and/or testosterone metabolites affect the 2D: 4D ratio requires further investigation.
Prenatal androgen-receptor activity has organizational morphological effects in mice
TLDR
It is shown in a mouse model that experimental manipulation of the prenatal androgen level leads to changes in the length of the fingers of all paws in males and females and also total paw length and the 2D:4D ratio was affected.
Testosterone enhancement during pregnancy influences social coping and gene expression of oxytocin and vasopressin in the brain of adult rats.
TLDR
The research showed that prenatal exposure to higher levels of testosterone activated socio‑cohesive and socio‑aversive interactions, but only in males, and testosterone enhancement in pregnancy could have long‑lasting effects on oxytocin and arginine-vasopressin levels in the brain of adult animals.
Testosterone production, sexually dimorphic morphology, and digit ratio in the dark-eyed junco
TLDR
It is concluded that individual variation in exposure to developmental hormones, as reflected by 2D:4D, is correlated with adult hormone production ability and sexually dimorphic morphology in adulthood, suggesting that endogenous variation in steroid hormone exposure may have long-term consequences similar to those seen in experimental manipulations.
Digit ratio (2D:4D) and month of birth: A link to the solstitial-melatonin-testosterone effect.
Maternal corticosterone but not testosterone level is associated with the ratio of second-to-fourth digit length (2D:4D) in field vole offspring (Microtus agrestis)
Criminality and the 2D:4D Ratio
  • L. Ellis, A. Hoskin
  • Psychology
    International journal of offender therapy and comparative criminology
  • 2015
TLDR
It is concluded that high exposure to androgens during prenatal development contributes to most forms of offending following the onset of puberty.
Digit ratio (2D:4D), aggression, and testosterone in men exposed to an aggressive video stimulus.
TLDR
It is concluded that 2D:4D moderates the impact of an aggressive stimulus on aggression, such that an increase in testosterone resulting from a "challenge" is associated with a negative correlation between 2D-4D and aggression.
Side-specific effect of yolk testosterone elevation on second-to-fourth digit ratio in a wild passerine
TLDR
This is the first study which shows experimentally that early testosterone exposure can affect second-to-fourth digit ratio in a wild population of a passerine bird.
Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
TLDR
Discrete T exposure during early-to-mid gestation in female rhesus monkeys thus appears to increase RH2D∶4D through right-side biased, non-skeletal tissue growth, which provides a complex biomarker for fetal T exposure.
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References

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TLDR
It is suggested that maternal testosterone may influence especially male postnatal open field strategies with respect to offsprings postnatal behavioral strategies in the open field.
Effects of neonatal androgens on open-field behavior and maze learning in the prepubescent and adult rat
Sexual dimorphism in digit‐length ratios of laboratory mice
TLDR
The mouse may be a useful animal model for studying the factors that influence finger length patterns, which have recently been correlated with several specific behaviors and disease predispositions in humans.
Relative digit lengths and testosterone levels in Guinea baboons
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TLDR
Gestation administration of 0.5 and 1 mg TP masculinizes female offspring without greatly affecting pup viability or pregnancy of the dam, and this study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities.
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TLDR
There is a peripubertal as well as a neonatal period when testosterone can act organisationally to masculinise or defeminise female rats, and potency between effects of neonatal and pubertal androgens was found on female body weights.
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TLDR
It is demonstrated that perinatal exposure to vinclozolin, an environmental antiandrogen, can alter androgen-dependent play behavior in the male rat.
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TLDR
Day 18 and possibly day 19 post conception represent a critical period during which the central nervous system of the male is primed by high levels of testosterone, and the process of masculinization is completed by exposure to testosterone levels that are relatively low and need not be consistently higher than those of female littermates.
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TLDR
The results suggest that the onset for altered reproductive morphology occurs at least as early as GD 16, whereas the onset of sexual behavior sensitivity occurs precisely at GD 18, and that the normal pattern of adult LH release in females is not altered by prenatal androgen treatment using this specific paradigm.
Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide
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