Testosterone eliminates the attenuating effect of castration on the progressive glomerular injury in hypercholesterolemic male Imai rats.

@article{Sakemi1994TestosteroneET,
  title={Testosterone eliminates the attenuating effect of castration on the progressive glomerular injury in hypercholesterolemic male Imai rats.},
  author={Takanobu Sakemi and Hideo Toyoshima and Fumitaka Morito},
  journal={Nephron},
  year={1994},
  volume={67 4},
  pages={469-76}
}
Hypercholesterolemic Imai rats, especially males, spontaneously develop proteinuria and glomerulosclerosis. We have shown that castration attenuated the progression of glomerular injury in male Imai rats. The present study was designed to investigate whether the attenuating effect of castration on glomerulosclerosis is eliminated by administration of testosterone. Testosterone propionate (TP) eliminated the attenuating effect of castration on the progression of glomerular injury by… CONTINUE READING

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