Testosterone dose-response relationships in healthy young men.

@article{Bhasin2001TestosteroneDR,
  title={Testosterone dose-response relationships in healthy young men.},
  author={Shalender Bhasin and Linda J. Woodhouse and Richard Casaburi and A B Singh and D Bhasin and Nancy Berman and X. Chen and Kevin E Yarasheski and Lynne Magliano and Connie Dzekov and Jeanne Dzekov and Rachelle Bross and Jeffrey Phillips and Indrani Sinha-Hikim and Ruoquing Shen and Thomas W Storer},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 6},
  pages={
          E1172-81
        }
}
Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent processes are similar. To determine the effects of graded doses of testosterone on body composition, muscle size, strength, power, sexual and cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, and insulin-like growth factor I (IGF-I… 
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In apparently healthy men, over a wide dose range, testosterone did not adversely affect atherogenic biomarkers and long-term studies with larger sample sizes are warranted to determine whether testosterone supplementation affects atherosclerosis progression and cardiovascular risk.
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