Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.

@article{Yarrow2014TestosteroneDD,
  title={Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.},
  author={Joshua F Yarrow and Christine F. Conover and Luke A. Beggs and Darren T. Beck and Dana M Otzel and Alexander Balaez and Sarah M Combs and Julie R Miller and Fan Ye and Jos{\'e} Ignacio Aguirre and Kathleen G Neuville and Alyssa A Williams and Bryan Conrad and Chris M. Gregory and Thomas J. Wronski and Prodip Bose and Stephen E. Borst},
  journal={Journal of neurotrauma},
  year={2014},
  volume={31 9},
  pages={834-45}
}
Androgen administration protects against musculoskeletal deficits in models of sex-steroid deficiency and injury/disuse. It remains unknown, however, whether testosterone prevents bone loss accompanying spinal cord injury (SCI), a condition that results in a near universal occurrence of osteoporosis. Our primary purpose was to determine whether testosterone-enanthate (TE) attenuates hindlimb bone loss in a rodent moderate/severe contusion SCI model. Forty (n=10/group), 14 week old male Sprague… CONTINUE READING