Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits.

@article{Pham2002TestosteroneDT,
  title={Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits.},
  author={Thai V. Pham and Evgeni Alekseevitch Sosunov and Evgeny P. Anyukhovsky and Peter R. Danilo and Michael R. Rosen},
  journal={Circulation},
  year={2002},
  volume={106 16},
  pages={
          2132-6
        }
}
BACKGROUND Recent clinical and experimental data suggest that testosterone may protect males against the deleterious effects of repolarization-prolonging drugs. This study tests the hypothesis that 5alpha-dihydrotestosterone (DHT) protects normal females against drug-induced excessive prolongation of repolarization. METHODS AND RESULTS We used microelectrode techniques to study isolated preparations of rabbit ventricular endocardium from age-matched normal control female rabbits and female… CONTINUE READING

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